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Exposure for the glucuronide metabolite is 35 to 40 moments bigger than publicity to your father or mother drug. In vitro info advise that hydromorphone in clinically pertinent concentrations has nominal opportunity to inhibit the action of human hepatic CYP450 enzymes like CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.fentanyl transmucosal and hydromorpho